Biomarkers role in controlling Dengue

Biomarkers role in controlling Dengue

Why in news?

In a Mumbai based research on dengue affirmed that biomarkers can help to control deaths induced by the disease.

Biomarkers and its Use

  • Biomarkers – Basically, these are indicators, which helps to establish the severity of a disease/chances of getting infected with a disease.
  • Ascertains on the bases of molecular signatures.
  • Provides an effectual understanding of the disease progression each person suffering from the disorder.

What are the symptoms of Dengue?

  • Spreads when an infected female Aedes Aegyptus mosquito bites an individual.
  • Dengue Haemorrhagic Fever (DHF) leads to deadly complexities for the infected person.
  • In its most severe form, DHF can cause Dengue Shock Syndrome (DSS).
  • DSS lets the blood pressure to drop down till critical levels which leads to start to the failure of vital organs, resulting very high mortality rate.

What is the status of dengue in India?

  • The earliest reported evidence of dengue occurrence in India was from Vellore district in Tamil Nadu in 1956.
  • Preliminary, the presence of dengue was only in urban areas, but steadily it spread across the country.
  • As per the National Vector Borne Disease Control Programme (NVBDCP) report In 2016 alone, the recorded number of dengue cases were 1, 29,166 which resulted in 245 deaths.

What are the outcomes of the study?

  • 100 to 150 samples were collected for the study, In these half of the samples were of dengue patients, who required ICU treatment.
  • Noteworthy point is, Not all the dengue cases amplify in DHF or DSS.
  • The main aim of the study was to find out a panel of protein biomarkers, which can be an answer in the prediction of the disease and the quantification of severity of the disease.
  • The study also aimed to develop a diagnostic kit to prevent critical disease progression.
  • It can be a game changer If a predictive test comes in place.
  • Forecast of disease progression will bring down avoidable hospitalizations.